Chromatography Resource Center

Part of Thermo Fisher Scientific

Study intended to evaluate post-translational modifications (PTMs) during enzymatic digestion of monoclonal antibodies using the Thermo Scientific™ SMART Digest™ kit

June 29, 2018

Application Benefits

  • A fast and simple protein digestion for peptide mapping analysis that results in low levels of sample preparation-induced post-translational modifications
  • Time to complete digestion considerably shorter than traditional methods, making it possible to achieve an efficient digestion even in 30 min
  • Workflow achieves 100% sequence coverage with high confidence
  • Analytical separation achieves outstanding reproducibility with retention time precision RSD <= 0.2%

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