Chromatography Resource Center

Part of Thermo Fisher Scientific

New High Performance Reversed-Phase LC Columns for Oligonucleotide and Large Double-Stranded DNA/RNA Analysis: DNAPac RP

May 6, 2016

High Performance Reversed-Phase LC Columns: The DNAPac RP column is based on spherical wide-pore 4µm polymer resin. The phase is highly stable to extremes of pH (0-14), and temperature (5-110°C), and operates with mobile phases compatible with direct mass spectrometry. The column may be operated in both HPLC and UHPLC instruments, producing high resolution at high throughput for oligonucleotides and resolves both small and very large dsDNA segments. DNAPac RP reversed phase (RP) column is specifically designed for separation of oligonucleotides and DNA/RNA fragments. The stationary phase is fully compatible with mass spectrometry friendly organic solvents and ion-pair reagents such as triethylamine (TEA) and hexylamine (HA). The wide pore size of polymer resin enables efficient separation of large nucleic acids with low carry-over.

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